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Test Code UPGD Uroporphyrinogen Decarboxylase, Whole Blood

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Whole blood


Ordering Guidance


Porphyria cutanea tarda (PCT) type I (sporadic), the most common form of PCT, exhibits normal erythrocyte enzyme activity. The preferred test for diagnosis of PCT type I is PQNU / Porphyrins, Quantitative, 24 Hour, Urine or PQNRU / Porphyrins, Quantitative, Random, Urine.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Patient Preparation: For 24 hours before specimen collection, patient must not consume any alcohol. This is essential as alcohol suppresses enzyme activity for 24 hours after ingestion.

Container/Tube:

Preferred: Green top (sodium heparin)

Acceptable: Lavender top (EDTA) or green top (lithium heparin)

Specimen Volume: 4 mL; full tube


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole blood Refrigerated (preferred) 14 days
  Ambient  7 days

Reference Values

≥1.00 RU (Normal)

0.80-0.99 RU (Indeterminate)

<0.80 RU (Indicative of porphyria cutanea tarda type II)

 

RU = Relative Units

Day(s) Performed

Tuesday

CPT Code Information

82657

Genetics Test Information

Uroporphyrinogen decarboxylase is deficient in cases of type II porphyria cutanea tarda (PCT). Enzyme analysis is uninformative in sporadic PCT cases.

Report Available

3 to 9 days

Specimen Retention Time

14 days

Reject Due To

Gross hemolysis Reject