Test Code RAVMP Ravulizumab Monitoring Panel, Serum
Ordering Guidance
To measure only serum concentration of ravulizumab, order RAVU / Ravulizumab, Serum.
Specimen Required
Patient Preparation:
1. Fasting: 8 hours, preferred but not required
2. Suggest discontinuing natalizumab at least 4 weeks before specimen collection for ravulizumab testing. Patient should consult the healthcare professional who prescribed this drug to determine if discontinuation is an option. If not, ok to proceed with testing while taking natalizumab.
Supplies: Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: 2 Plastic vials
Specimen Volume: 2 mL in 2 plastic vials, each vial containing 1 mL
Collection Instructions:
1. Draw blood immediately before next scheduled dose.
2. Immediately after specimen collection, place the tube on wet ice.
3. After specimen has clotted on wet ice, centrifuge at 4° C and aliquot serum into two 5 mL plastic vials.
4. Freeze serum within 30 minutes of centrifugation. Serum must be placed on dry ice if not frozen immediately.
Specimen Type
SerumSerum Red
Specimen Minimum Volume
1 mL in 2 plastic vials, each vial containing 0.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time |
---|---|---|
Serum | Frozen | 14 days |
Serum Red | Frozen | 14 days |
Reject Due To
Gross hemolysis | Reject |
Gross lipemia | Reject |
Gross icterus | OK |
Reference Values
RAVULIZUMAB COMPLEMENT BLOCKAGE:
≥46% normal
RAVULIZUMAB:
Lower limit of quantitation =5.0 mcg/mL
>175 mcg/mL: Therapeutic concentration for paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome
Day(s) Performed
Varies
Report Available
3 to 10 daysSpecimen Retention Time
14 daysPerforming Laboratory

CPT Code Information
80299
86161