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HelpTest Code PCPRO Plasma Cell DNA Content and Proliferation, Bone Marrow
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Bone MarrowOrdering Guidance
This test can be ordered at diagnosis or follow-up of a plasma cell neoplasm (plasma cell proliferative disorder).
If reflex fluorescence in situ hybridization (FISH) testing is desired, order MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report, Bone Marrow.
For follow-up of a plasma cell neoplasm (plasma cell proliferative disorder), order MSMRD / Myeloma Stratification and Risk-Adapted Therapy with Reflex to Measurable/Minimal Residual Disease, Bone Marrow, could be considered.
Necessary Information
Include patient's disease state (untreated, treated, monoclonal gammopathy of undetermined significance, stable).
Specimen Required
Specimen Type: Redirected bone marrow
Preferred: Yellow top (ACD solution A or B)
Acceptable: Lavender top (EDTA) or green top (sodium heparin)
Specimen Volume: 4 mL
Specimen Stability Information: 3 days
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Bone Marrow | Ambient (preferred) | |
| Refrigerated | ||
Reference Values
Plasma Cell Clonality:
Normal bone marrow
No monotypic clonal plasma cells detected
DNA Index:
Normal polytypic plasma cells
DNA index (G0/G1 cells): Diploid 0.95-1.05
Day(s) Performed
Monday through Saturday
CPT Code Information
88182-Flow cytometry, cell cycle or DNA analysis
88184-Flow cytometry; first cell surface, cytoplasmic or nuclear marker
88185 x 5-Flow cytometry; additional cell surface, cytoplasmic or nuclear marker (each)
88187-Flow cytometry interpretation, 2 to 8 Markers (added as FCINT)
Report Available
1 to 4 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | Reject |
| Fully clotted | Reject |