Sign in →

Test Code MP9W Mucopolysaccharidoses, Nine-Enzyme Panel, Leukocytes


Ordering Guidance


To evaluate newborn patients in follow-up to an abnormal newborn screen for MPS I, the recommended tests are IDUAW / Alpha-L-Iduronidase, Leukocytes and MPSBS / Mucopolysaccharidosis, Blood Spot, MPSWB / Mucopolysaccharidosis, Blood), MPSER / Mucopolysaccharides Quantitative, Serum or MPSQU / Mucopolysaccharides Quantitative, Random, Urine.

 

To evaluate newborn patients in follow-up to an abnormal newborn screen for MPS II, the recommended tests are I2SB / Iduronate-2-Sulfatase, Blood Spot or I2SWB / Iduronate-2-Sulfatase, Leukocytes and MPSBS / Mucopolysaccharidosis, Blood Spot, MPSWB / Mucopolysaccharidosis, Blood, MPSER / Mucopolysaccharides Quantitative, Serum or MPSQU / Mucopolysaccharides Quantitative, Random, Urine.



Shipping Instructions


For optimal isolation of leukocytes, it is recommended the specimen arrive refrigerated within 6 days of collection to be stabilized. Collect specimen Monday through Thursday only and not the day before a holiday. Specimen should be collected and packaged as close to shipping time as possible.



Necessary Information


1. Patient's age is required.

2. Reason for testing is required.



Specimen Required


Container/Tube:

Preferred: Yellow top (ACD solution B)

Acceptable: Yellow top (ACD solution A) or lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.


Specimen Type

Whole Blood ACD

Specimen Minimum Volume

5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood ACD Refrigerated (preferred) 6 days
  Ambient  6 days

Reject Due To

Gross hemolysis Reject

Reference Values

Iduronate-2-sulfatase: >2.20 nmol/hour/mg protein

 

Heparan-N-sulfatase: >0.13 nmol/hour/mg protein

 

N-acetyl-alpha-D-glucosaminidase: >0.09 nmol/hour/mg protein

 

Heparan-alpha-glucosaminide N-acetyltransferase: >0.24 nmol/hou/mg protein

 

N-acetylglucosamine-6-sulfatase: >0.03 nmol/hour/mg protein

 

N-acetylgalactosamine-6-sulfatase: >1.60 nmol/hour/mg protein

 

Beta-galactosidase: >0.28 nmol/hour/mg protein

 

Arylsulfatase B: >0.34 nmol/hour/mg protein

 

Beta-glucuronidase: >3.50 nmol/hour/mg protein

 

An interpretive report will be provided.

Day(s) Performed

Preanalytical processing: Monday through Saturday

Testing performed: Tuesday

Report Available

8 to 15 days

Specimen Retention Time

WBC homogenate: 1 month

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82657