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Test Code LAD1 Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping, Blood

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Whole Blood EDTA


Shipping Instructions


Testing is not performed on Saturday, Sunday, or observed holidays. Only collect and ship specimens for arrival on days when testing is performed.

 

Specimens received on days when testing is not performed or after 5 p.m. Central on Friday will be canceled if specimen is outside of stability when testing is next performed.

 

Collect and package specimen as close to shipping time as possible. It is recommended that specimens arrive within 24 hours of collection.



Necessary Information


Date and time of collection and healthcare professional name and phone number are required.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 5 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.

Additional Information: For serial monitoring, it is recommended that specimens are collected at the same time of day.


Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Ambient 72 hours PURPLE OR PINK TOP/EDTA

Reference Values

Normal (reported as normal or absent expression for each marker)

Day(s) Performed

Monday through Friday

CPT Code Information

86356 x 3

Report Available

3 to 4 days

Specimen Retention Time

4 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Genetics Test Information

ITGB2 is located on the long arm of chromosome 21(21q22.3). It encodes the common beta 2 integrin subunit (CD18), which is necessary for the expression of lymphocyte function-associated antigen 1 (CD11a/CD18), Mac-1/CR3 (CD11b/CD18), and p150/95 (CD11c/CD18).

 

Variants in this gene are the underlying cause for the autosomal recessive leukocyte adhesion deficiency type 1.