Ordering Guidance

The preferred test for evaluating adults for an inherited disorder of methionine, cobalamin, or propionate metabolism is CMMPP / Cobalamin, Methionine, and Methylmalonic Acid Pathways, Plasma or CMMPS / Cobalamin, Methionine, and Methylmalonic Acid Pathways, Serum.

Specimen Required

Supplies: Card-Blood Spot Collection (Filter Paper) (T493)

Container/Tube:

Preferred: Card-Blood Spot Collection (Filter Paper)

Acceptable: Local newborn screening card, Whatman Protein Saver 903 filter paper, PerkinElmer 226 (formerly Ahlstrom 226) filter paper, Munktell filter paper

Specimen Volume: 2 Blood spots

Collection Instructions:

1. Do not use device or capillary tube containing EDTA or ACD to collect specimen. Sodium heparin is acceptable but must be spotted on card the same day as collected.

2. Completely fill at least 2 circles on the filter paper card (approximately 100 microliters blood per circle) using blood from a heel or finger stick.

3. Let blood dry on filter paper at ambient temperature in a horizontal position for a minimum of 3 hours.

4. Do not expose specimen to heat or direct sunlight.

5. Do not stack wet specimens.

6. Keep specimen dry.

Additional Information:

1. For collection instructions, see Blood Spot Collection Instructions

2. For collection instructions in Spanish, see Blood Spot Collection Card-Spanish Instructions (T777)

3. For collection instructions in Chinese, see Blood Spot Collection Card-Chinese Instructions (T800)