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Test Code DCLNG Dilated Cardiomyopathy and Left Ventricular Noncompaction Cardiomyopathy Gene Panel, Varies


Ordering Guidance


This test is intended for genetic screening for and diagnosis of dilated cardiomyopathy or left ventricular noncompaction.

 

For comprehensive cardiomyopathy genetic testing, order CCMGG / Comprehensive Cardiomyopathy Gene Panel, Varies.

 

Customization of this panel and single gene analysis for any gene present on this panel are available. For more information see CGPH / Custom Gene Panel, Hereditary, Next-Generation Sequencing, Varies.

 

Targeted testing for familial variants (also called site-specific or known mutations testing) is available for the genes on this panel. See FMTT / Familial Variant, Targeted Testing, Varies. To obtain more information about this testing option, call 800-533-1710.



Shipping Instructions


Specimen preferred to arrive within 96 hours of collection.



Necessary Information


Prior Authorization is available, but not required, for this test. If proceeding with the prior authorization process, submit the required form with the specimen.



Specimen Required


Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood

Container/Tube:

Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send whole blood specimen in original tube. Do not aliquot.

Specimen Stability Information: Ambient (preferred)/Refrigerated


Genetics Test Information

This test utilizes next-generation sequencing to detect single nucleotide and copy number variants in 63 genes associated with hereditary forms of dilated cardiomyopathy and left ventricular noncompaction: ABCC9, ACAD9, ACADVL, ACTC1, ACTN2, ALMS1, ALPK3, BAG3, CDH2, CPT2, CRYAB, CSRP3, DES, DMD, DNAJC19, DOLK, DSC2, DSG2, DSP, EMD, FKRP, FKTN, FLNC, GAA, GLA, HCN4, JPH2, JUP, LAMP2, LMNA, MYBPC3, MYH7, MYLK3, MYPN, NEXN, NKX2-5, PCCA, PCCB, PKP2, PLN, PPA2, PPCS, PRDM16, RAF1, RBM20, RYR2, SCN5A, SGCD, SHOC2, SLC22A5, TAZ (TAFAZZIN), TBX20, TCAP, TMEM43, TMEM70, TNNC1, TNNI3, TNNI3K, TNNT2, TPM1, TTN, TTR, and VCL. See Targeted Genes and Methodology Details for Dilated Cardiomyopathy and Left Ventricular Noncompaction Cardiomyopathy Gene Panel and Method Description for additional details.

 

Identification of a disease-causing variant may assist with diagnosis, prognosis, clinical management, familial screening, and genetic counseling for hereditary forms of dilated cardiomyopathy and left ventricular noncompaction.

 

Prior Authorization is available for this assay.

Specimen Type

Varies

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability

Reference Values

An interpretive report will be provided.

Day(s) Performed

Varies

Report Available

14 to 28 days

Specimen Retention Time

Whole blood: 2 weeks (if available); Extracted DNA: 3 months

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

81439