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HelpTest Code CRDPU Creatine Disorders Panel, Random, Urine
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
UrineNecessary Information
Patient's age and sex are required.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10 mL urine tube
Specimen Volume: 1 mL
Collection Instructions:
1. Collect a random urine specimen.
2. Immediately freeze urine specimen.
3. If possible, do not send other tests ordered on same vial of urine. In doing so, the other tests may have increased turnaround time due to the strict frozen criteria of this assay.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen | 29 days |
Reference Values
Males
|
Age |
Creatinine (nmol/mL) |
Guanidinoacetate (nmol/mL) |
Creatine (nmol/mL) |
Creatine/ creatinine |
|
≤31 days |
430-5,240 |
9-210 |
12-2,930 |
0.02-0.93 |
|
32 days-23 months |
313-9,040 |
16-860 |
18-10,490 |
0.02-2.49 |
|
2-4 years |
1,140-12,820 |
90-1,260 |
200-9,210 |
0.04-1.75 |
|
5-18 years |
1,190-25,270 |
40-1,190 |
60-9,530 |
0.01-0.96 |
|
>18 years (male) |
3,854-23,340 |
30-710 |
7-470 |
0.00-0.04 |
Females
|
Age |
Creatinine (nmol/mL) |
Guanidinoacetate (nmol/mL) |
Creatine (nmol/mL) |
Creatine/ creatinine |
|
≤31 days |
430-5,240 |
9-210 |
12-2,930 |
0.02-0.93 |
|
32 days-23 months |
313-9,040 |
16-860 |
18-10,490 |
0.02-2.49 |
|
2-4 years |
1,140-12,820 |
90-1,260 |
200-9,210 |
0.04-1.75 |
|
5-18 years |
1,190-25,270 |
40-1,190 |
60-9,530 |
0.01-0.96 |
|
>18 years |
1,540-18,050 |
30-760 |
5-2810 |
0.00-0.46 |
Day(s) Performed
Tuesday
CPT Code Information
82540
82570
82542
Report Available
3 to 9 daysSpecimen Retention Time
1 monthReject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Genetics Test Information
Depletion of cerebral creatine occurs in all 3 types of creatine deficiency syndromes (CDS): arginine:glycine amidinotransferase deficiency, guanidinoacetate methyltransferase deficiency, and creatine transporter (SLC6A8) deficiency.
Measurement of guanidinoacetate, creatine (Cr), and creatinine (Crn) in urine, along with the Cr:Crn ratio, aids in distinguishing the types of creatine deficiency syndromes.
Treatment with oral creatine supplementation is effective in some types of CDS.
Creatine supplementation may cause increased creatine values.