Creatine Disorders Panel, Serum - Central Peninsula Hospital

Ordering Guidance

For additional diagnostic testing, consider ordering CRDPU / Creatine Disorders Panel, Random, Urine.

Additional Testing Requirements

To diagnose all creatine deficiency syndromes, order CRDPU / Creatine Disorders Panel, Random, Urine in addition to this test.

Necessary Information

Patient's age and sex are required.

Specimen Required

Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial. Send serum frozen.

Genetics Test Information

Depletion of cerebral creatine occurs in all 3 types of creatine deficiency syndromes (CDS): arginine:glycine amidinotransferase deficiency, guanidinoacetate methyltransferase deficiency, and creatine transporter deficiency.

Measurement of guanidinoacetate, creatine, and creatinine, along with associated analyte ratios in serum and urine, aids in distinguishing the types of creatine deficiency syndromes.

Treatment with oral creatine supplementation is effective in some types of CDS.

Creatine supplementation may impact reliability of test results.

Specimen Type

Serum

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Frozen (preferred)	14 days
	Refrigerated	7 days
	Ambient	72 hours

Reject Due To

Gross hemolysis	OK
Gross lipemia	OK
Gross icterus	OK

Reference Values

Creatine Disorders Panel Reference Values (creatine, creatinine, and guanidinoacetate results reported as nmol/mL)
	≤11 Months		12-23 Months		24-35 Months
	Female	Male	Female	Male	Female	Male
Creatine	38.6-96.8	39.0-97.0	38.2-96.5	38.6-96.5	37.7-96.0	38.2-96.0
Creatinine	27.6-35.9	27.6-35.2	27.6-36.5	27.6-35.5	27.6-37.1	27.6-36.0
Guanidinoacetate	0.7-2.0	0.7-2.1	0.7-2.0	0.7-2.1	0.7-2.0	0.7-2.1
Creatine/ creatinine	≤3.07	≤3.60	≤3.02	≤3.54	≤2.96	≤3.48
Guanidinoacetate/ creatine	≤0.040	≤0.040	≤0.042	≤0.040	≤0.043	≤0.042
Guanidinoacetate/ creatinine	≤0.051	≤0.081	≤0.051	≤0.080	≤0.051	≤0.079

	3 Years		4 Years		5 Years
	Female	Male	Female	Male	Female	Male
Creatine	37.1-95.5	37.7-95.3	36.0-94.4	36.8-94.1	34.6-93.2	35.6-92.7
Creatinine	27.6-37.9	27.7-36.9	27.6-39.3	27.7-38.2	27.6-40.9	27.8-39.9
Guanidinoacetate	0.7-2.1	0.7-2.2	0.7-2.1	0.7-2.2	0.7-2.1	0.7-2.2
Creatine/ creatinine	≤2.89	≤3.40	≤2.77	≤3.26	≤2.64	≤3.09
Guanidinoacetate/ creatine	≤0.045	≤0.043	≤0.049	≤0.045	≤0.053	≤0.049
Guanidinoacetate/ creatinine	≤0.050	≤0.077	≤0.050	≤0.075	≤0.049	≤0.072

	6 Years		7 Years		8 Years
	Female	Male	Female	Male	Female	Male
Creatine	33.0-91.7	34.3-91.0	31.2-90.0	32.7-89.2	29.2-88.1	31.0-87.3
Creatinine	27.6-42.8	28.0-41.9	27.7-44.9	28.3-44.3	27.8-47.0	28.8-47.1
Guanidinoacetate	0.7-2.1	0.7-2.3	0.7-2.1	0.8-2.3	0.8-2.1	0.8-2.4
Creatine/ creatinine	≤2.49	≤2.91	≤2.33	≤2.70	≤2.17	≤2.49
Guanidinoacetate/ creatine	≤0.058	≤0.053	≤0.063	≤0.058	≤0.069	≤0.064
Guanidinoacetate/ creatinine	≤0.049	≤0.069	≤0.048	≤0.066	≤0.047	≤0.063

	9 Years		10 Years		11 Years
	Female	Male	Female	Male	Female	Male
Creatine	27.2-85.9	29.3-85.2	25.2-83.7	27.4-83.1	23.4-81.3	25.7-80.9
Creatinine	28.0-49.3	29.5-50.1	28.2-51.5	30.6-53.6	28.4-53.6	32.0-57.2
Guanidinoacetate	0.8-2.2	0.8-2.5	0.9-2.2	0.9-2.6	0.9-2.2	1.0-2.6
Creatine/ creatinine	≤2.02	≤2.28	≤1.86	≤2.07	≤1.72	≤1.87
Guanidinoacetate/ creatine	≤0.075	≤0.070	≤0.081	≤0.078	≤0.087	≤0.085
Guanidinoacetate/ creatinine	≤0.047	≤0.060	≤0.046	≤0.057	≤0.045	≤0.055

	12 Years		13 Years		14 Years
	Female	Male	Female	Male	Female	Male
Creatine	21.7-78.7	23.9-78.6	20.3-76.2	22.3-76.2	19.0-73.6	20.8-73.8
Creatinine	28.7-55.7	33.8-61.0	29.1-57.7	35.9-64.8	29.5-59.5	38.1-68.5
Guanidinoacetate	0.9-2.2	1.0-2.7	1.0-2.3	1.1-2.8	1.0-2.3	1.1-2.9
Creatine/ creatinine	≤1.58	≤1.68	≤1.45	≤1.50	≤1.33	≤1.34
Guanidinoacetate/ creatine	≤0.092	≤0.093	≤0.097	≤0.101	≤0.101	≤0.109
Guanidinoacetate/ creatinine	≤0.044	≤0.053	≤0.043	≤0.051	≤0.042	≤0.050

	15 Years		16 Years		17 Years
	Female	Male	Female	Male	Female	Male
Creatine	18.1-71.1	19.5-71.2	17.4-68.7	18.4-68.6	16.9-66.5	17.4-65.9
Creatinine	29.9-61.3	40.4-71.9	30.4-62.9	42.4-75.0	30.9-64.4	44.2-77.6
Guanidinoacetate	1.0-2.3	1.2-2.9	1.1-2.3	1.3-3.0	1.1-2.3	1.3-3.1
Creatine/ creatinine	≤1.22	≤1.20	≤1.12	≤1.07	≤1.04	≤0.97
Guanidinoacetate/ creatine	≤0.104	≤0.117	≤0.107	≤0.125	≤0.109	≤0.132
Guanidinoacetate/ creatinine	≤0.041	≤0.049	≤0.040	≤0.048	≤0.040	≤0.048

	18 Years		19 Years		20 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.7-64.4	16.6-63.3	16.6-62.7	15.8-60.7	16.5-61.1	15.2-58.3
Creatinine	31.3-65.8	45.6-80.0	31.8-67.0	46.7-82.0	32.2-68.2	47.4-83.9
Guanidinoacetate	1.1-2.4	1.4-3.1	1.1-2.4	1.4-3.2	1.1-2.4	1.5-3.2
Creatine/ creatinine	≤0.98	≤0.87	≤0.93	≤0.80	≤0.89	≤0.73
Guanidinoacetate/ creatine	≤0.111	≤0.139	≤0.112	≤0.145	≤0.113	≤0.150
Guanidinoacetate/ creatinine	≤0.039	≤0.047	≤0.038	≤0.047	≤0.038	≤0.046

	21 Years		22 Years		23 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.6-59.8	14.7-56.0	16.6-58.8	14.2-54.0	16.7-57.9	13.7-52.2
Creatinine	32.5-69.2	47.9-85.6	32.8-70.2	48.2-87.2	33.1-71.1	48.4-88.8
Guanidinoacetate	1.1-2.4	1.5-3.2	1.1-2.5	1.5-3.3	1.1-2.5	1.6-3.3
Creatine/ creatinine	≤0.87	≤0.68	≤0.85	≤0.64	≤0.84	≤0.61
Guanidinoacetate/ creatine	≤0.114	≤0.156	≤0.115	≤0.161	≤0.116	≤0.165
Guanidinoacetate/ creatinine	≤0.037	≤0.045	≤0.037	≤0.045	≤0.037	≤0.044

	24 Years		25 Years		26 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.7-57.2	13.3-50.6	16.7-56.5	12.9-49.3	16.7-56.0	12.5-48.1
Creatinine	33.3-71.9	48.6-90.2	33.6-72.8	48.7-91.5	33.7-73.6	48.9-92.7
Guanidinoacetate	1.1-2.5	1.6-3.3	1.1-2.5	1.6-3.3	1.1-2.6	1.6-3.4
Creatine/ creatinine	≤0.84	≤0.58	≤0.84	≤0.56	≤0.84	≤0.54
Guanidinoacetate/ creatine	≤0.116	≤0.170	≤0.117	≤0.174	≤0.118	≤0.179
Guanidinoacetate/ creatinine	≤0.036	≤0.043	≤0.036	≤0.043	≤0.036	≤0.042

	27 Years		28 Years		29 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.7-55.5	12.1-47.1	16.6-55.1	11.8-46.3	16.5-54.7	11.5-45.4
Creatinine	33.9-74.4	49.0-93.7	34.1-75.2	49.1-94.5	34.2-76.0	49.2-95.3
Guanidinoacetate	1.1-2.6	1.6-3.4	1.1-2.6	1.6-3.4	1.1-2.6	1.6-3.4
Creatine/ creatinine	≤0.84	≤0.52	≤0.84	≤0.51	≤0.84	≤0.49
Guanidinoacetate/ creatine	≤0.118	≤0.182	≤0.119	≤0.186	≤0.119	≤0.188
Guanidinoacetate/ creatinine	≤0.036	≤0.042	≤0.036	≤0.041	≤0.036	≤0.041

	30 Years		31 Years		32 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.4-54.2	11.3-44.7	16.4-53.8	11.1-43.9	16.3-53.4	11.0-43.2
Creatinine	34.4-76.8	49.3-96.0	34.6-77.5	49.3-96.7	34.7-78.2	49.4-97.4
Guanidinoacetate	1.2-2.7	1.6-3.5	1.2-2.7	1.6-3.5	1.2-2.7	1.6-3.5
Creatine/ creatinine	≤0.84	≤0.48	≤0.83	≤0.47	≤0.83	≤0.46
Guanidinoacetate/ creatine	≤0.120	≤0.190	≤0.120	≤0.192	≤0.119	≤0.192
Guanidinoacetate/ creatinine	≤0.036	≤0.041	≤0.036	≤0.042	≤0.037	≤0.042

	33 Years		34 Years		35 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.3-53.0	10.9-42.5	16.4-52.7	10.8-41.7	16.4-52.3	10.7-41.0
Creatinine	34.9-78.8	49.4-98.0	35.1-79.4	49.5-98.6	35.3-79.9	49.5-99.2
Guanidinoacetate	1.2-2.8	1.6-3.5	1.2-2.8	1.6-3.5	1.2-2.8	1.6-3.4
Creatine/ creatinine	≤0.82	≤0.45	≤0.82	≤0.45	≤0.82	≤0.44
Guanidinoacetate/ creatine	≤0.119	≤0.192	≤0.118	≤0.191	≤0.118	≤0.189
Guanidinoacetate/ creatinine	≤0.037	≤0.042	≤0.037	≤0.042	≤0.037	≤0.042

	36 Years		37 Years		38 Years
	Female	Male	Female	Male	Female	Male
Creatine	16.5-52.0	10.7-40.2	16.7-51.6	10.6-39.5	16.9-51.3	10.6-38.9
Creatinine	35.4-80.3	49.5-99.8	35.6-80.7	49.5-100.3	35.8-81.0	49.6-100.8
Guanidinoacetate	1.2-2.8	1.6-3.4	1.2-2.8	1.6-3.4	1.2-2.9	1.6-3.4
Creatine/ creatinine	≤0.82	≤0.44	≤0.82	≤0.44	≤0.83	≤0.44
Guanidinoacetate/ creatine	≤0.117	≤0.187	≤0.115	≤0.184	≤0.114	≤0.182
Guanidinoacetate/ creatinine	≤0.037	≤0.042	≤0.037	≤0.042	≤0.036	≤0.042

	39 Years		40 Years		41 Years
	Female	Male	Female	Male	Female	Male
Creatine	17.1-51.1	10.6-38.2	17.3-50.9	10.7-37.7	17.5-50.8	10.7-37.2
Creatinine	35.9-81.4	49.6-101.3	36.0-81.6	49.6-101.7	36.1-81.9	49.7-102.1
Guanidinoacetate	1.2-2.9	1.6-3.4	1.2-2.9	1.6-3.4	1.2-2.9	1.6-3.4
Creatine/ creatinine	≤0.83	≤0.44	≤0.83	≤0.44	≤0.84	≤0.44
Guanidinoacetate/ creatine	≤0.113	≤0.179	≤0.111	≤0.176	≤0.110	≤0.174
Guanidinoacetate/ creatinine	≤0.036	≤0.041	≤0.036	≤0.041	≤0.036	≤0.040

	42 Years		43 Years		44 Years
	Female	Male	Female	Male	Female	Male
Creatine	17.7-50.8	10.8-36.7	17.8-50.8	10.9-36.3	17.8-50.9	11.0-36.0
Creatinine	36.2-82.1	49.7-102.5	36.3-82.4	49.8-102.8	36.4-82.6	49.8-103.1
Guanidinoacetate	1.2-3.0	1.6-3.3	1.2-3.0	1.6-3.3	1.2-3.0	1.6-3.3
Creatine/ creatinine	≤0.84	≤0.44	≤0.84	≤0.43	≤0.84	≤0.43
Guanidinoacetate/ creatine	≤0.109	≤0.172	≤0.108	≤0.171	≤0.107	≤0.170
Guanidinoacetate/ creatinine	≤0.036	≤0.039	≤0.036	≤0.039	≤0.036	≤0.038

	45 Years		46 Years		47 Years
	Female	Male	Female	Male	Female	Male
Creatine	17.7-51.0	11.1-35.6	17.6-51.2	11.2-35.3	17.4-51.4	11.3-35.1
Creatinine	36.4-82.8	49.9-103.4	36.5-83.0	49.9-103.6	36.5-83.2	49.9-103.9
Guanidinoacetate	1.2-3.0	1.7-3.3	1.2-3.1	1.7-3.3	1.2-3.1	1.7-3.3
Creatine/ creatinine	≤0.84	≤0.42	≤0.83	≤0.41	≤0.83	≤0.40
Guanidinoacetate/ creatine	≤0.106	≤0.169	≤0.106	≤0.168	≤0.106	≤0.167
Guanidinoacetate/ creatinine	≤0.037	≤0.038	≤0.037	≤0.037	≤0.037	≤0.037

	48 Years		49 Years		50 Years
	Female	Male	Female	Male	Female	Male
Creatine	17.2-51.7	11.5-34.8	17.1-51.9	11.6-34.6	17.0-52.1	11.7-34.4
Creatinine	36.6-83.4	49.9-104.1	36.6-83.5	49.9-104.2	36.7-83.7	49.9-104.4
Guanidinoacetate	1.2-3.1	1.7-3.3	1.2-3.1	1.7-3.3	1.2-3.1	1.7-3.3
Creatine/ creatinine	≤0.82	≤0.39	≤0.82	≤0.38	≤0.82	≤0.38
Guanidinoacetate/ creatine	≤0.106	≤0.166	≤0.106	≤0.164	≤0.105	≤0.163
Guanidinoacetate/ creatinine	≤0.038	≤0.036	≤0.038	≤0.036	≤0.039	≤0.036

	51 Years		52 Years		53 Years
	Female	Male	Female	Male	Female	Male
Creatine	17.0-52.2	11.9-34.3	17.1-52.3	12.0-34.3	17.3-52.4	12.2-34.3
Creatinine	36.8-83.9	49.8-104.6	36.8-84.0	49.8-104.8	36.9-84.2	49.8-104.9
Guanidinoacetate	1.2-3.1	1.7-3.3	1.2-3.1	1.7-3.2	1.2-3.1	1.6-3.2
Creatine/ creatinine	≤0.82	≤0.37	≤0.82	≤0.37	≤0.82	≤0.38
Guanidinoacetate/ creatine	≤0.105	≤0.161	≤0.104	≤0.159	≤0.103	≤0.157
Guanidinoacetate/ creatinine	≤0.039	≤0.036	≤0.039	≤0.036	≤0.039	≤0.036

	54 Years		55 Years		56 Years
	Female	Male	Female	Male	Female	Male
Creatine	17.6-52.5	12.4-34.3	18.1-52.6	12.5-34.4	18.6-52.7	12.6-34.4
Creatinine	37.0-84.4	49.8-105.0	37.1-84.5	49.8-105.2	37.2-84.7	49.8-105.3
Guanidinoacetate	1.2-3.1	1.6-3.2	1.2-3.1	1.6-3.2	1.2-3.1	1.6-3.2
Creatine/ creatinine	≤0.82	≤0.38	≤0.83	≤0.39	≤0.84	≤0.40
Guanidinoacetate/ creatine	≤0.102	≤0.155	≤0.100	≤0.154	≤0.099	≤0.152
Guanidinoacetate/ creatinine	≤0.039	≤0.036	≤0.039	≤0.036	≤0.039	≤0.036

	57 Years		58 Years		59 Years
	Female	Male	Female	Male	Female	Male
Creatine	19.2-52.9	12.7-34.4	19.9-53.1	12.8-34.3	20.5-53.3	12.8-34.2
Creatinine	37.3-84.9	49.8-105.4	37.4-85.1	49.8-105.5	37.6-85.2	49.8-105.6
Guanidinoacetate	1.2-3.0	1.6-3.2	1.3-3.0	1.6-3.2	1.3-3.0	1.6-3.2
Creatine/ creatinine	≤0.84	≤0.40	≤0.85	≤0.41	≤0.86	≤0.42
Guanidinoacetate/ creatine	≤0.098	≤0.151	≤0.096	≤0.151	≤0.095	≤0.150
Guanidinoacetate/ creatinine	≤0.039	≤0.036	≤0.038	≤0.036	≤0.038	≤0.036

	60 Years		61 Years		62 Years
	Female	Male	Female	Male	Female	Male
Creatine	21.0-53.6	12.8-34.1	21.5-53.9	12.7-34.0	21.9-54.2	12.6-33.9
Creatinine	37.8-85.4	49.9-105.7	38.0-85.5	49.9-105.9	38.3-85.7	49.9-106.0
Guanidinoacetate	1.3-2.9	1.6-3.2	1.3-2.9	1.6-3.1	1.3-2.9	1.6-3.1
Creatine/ creatinine	≤0.87	≤0.43	≤0.87	≤0.44	≤0.88	≤0.44
Guanidinoacetate/ creatine	≤0.094	≤0.150	≤0.093	≤0.150	≤0.093	≤0.150
Guanidinoacetate/ creatinine	≤0.037	≤0.036	≤0.036	≤0.035	≤0.036	≤0.035

	63 Years		64 Years		65 Years
	Female	Male	Female	Male	Female	Male
Creatine	22.2-54.6	12.4-33.7	22.3-55.0	12.3-33.6	22.5-55.5	12.2-33.4
Creatinine	38.7-85.8	50.0-106.1	39.1-85.9	50.0-106.3	39.6-86.1	50.1-106.4
Guanidinoacetate	1.3-2.8	1.6-3.1	1.3-2.8	1.6-3.1	1.3-2.8	1.6-3.1
Creatine/ creatinine	≤0.88	≤0.45	≤0.89	≤0.46	≤0.89	≤0.46
Guanidinoacetate/ creatine	≤0.092	≤0.150	≤0.092	≤0.149	≤0.091	≤0.149
Guanidinoacetate/ creatinine	≤0.035	≤0.035	≤0.034	≤0.034	≤0.034	≤0.034

	66 Years		67 Years		68 Years
	Female	Male	Female	Male	Female	Male
Creatine	22.6-55.9	12.3-33.1	22.7-56.3	12.3-32.8	22.9-56.7	12.5-32.4
Creatinine	40.2-86.2	50.2-106.6	40.7-86.3	50.3-106.7	41.3-86.5	50.4-106.9
Guanidinoacetate	1.3-2.7	1.6-3.1	1.3-2.7	1.6-3.0	1.4-2.7	1.6-3.0
Creatine/ creatinine	≤0.90	≤0.47	≤0.90	≤0.48	≤0.90	≤0.48
Guanidinoacetate/ creatine	≤0.091	≤0.149	≤0.090	≤0.148	≤0.090	≤0.148
Guanidinoacetate/ creatinine	≤0.034	≤0.034	≤0.033	≤0.034	≤0.033	≤0.034

	69 Years		70 Years		≥ 71 Years
	Female	Male	Female	Male	Female	Male
Creatine	23.2-57.0	12.8-32.0	23.6-57.2	13.1-31.4	24.1-57.3	13.6-30.8
Creatinine	41.9-86.6	50.5-107.1	42.4-86.8	50.7-107.4	42.8-86.9	50.8-107.6
Guanidinoacetate	1.4-2.6	1.6-3.0	1.4-2.6	1.6-3.0	1.4-2.5	1.5-3.0
Creatine/ creatinine	≤0.90	≤0.48	≤0.90	≤0.48	≤0.90	≤0.48
Guanidinoacetate/ creatine	≤0.090	≤0.148	≤0.090	≤0.148	≤0.090	≤0.148
Guanidinoacetate/ creatinine	≤0.033	≤0.034	≤0.033	≤0.034	≤0.033	≤0.034

Day(s) Performed

Tuesday

Report Available

3 to 9 days

Specimen Retention Time

1 month

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82540

82565

82542

Central Peninsula Hospital powered by Mayo Clinic Laboratories

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Test Code CRDPS Creatine Disorders Panel, Serum