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Test Code CRDPP Creatine Disorders Panel, Plasma


Ordering Guidance


For additional diagnostic testing, consider ordering CRDPU / Creatine Disorders Panel, Random, Urine.



Additional Testing Requirements


To diagnose all creatine deficiency syndromes, order CRDPU / Creatine Disorders Panel, Random, Urine in addition to this test.



Necessary Information


Patient's age and sex are required.



Specimen Required


Collection Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Green top (sodium heparin), yellow top (ACD)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot plasma into plastic vial. Send plasma frozen.


Genetics Test Information

Depletion of cerebral creatine occurs in all 3 types of creatine deficiency syndromes (CDS): arginine:glycine amidinotransferase deficiency, guanidinoacetate methyltransferase deficiency, and creatine transporter deficiency.

 

Measurement of guanidinoacetate, creatine, and creatinine, along with associated analyte ratios in plasma and urine, aids in distinguishing the types of creatine deficiency syndromes.

 

Treatment with oral creatine supplementation is effective in some types of CDS.

 

Creatine supplementation may impact reliability of test results.

Specimen Type

Plasma

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Frozen (preferred) 14 days
  Refrigerated  7 days
  Ambient  72 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Creatine Disorders Panel Reference Values
(creatine, creatinine, and guanidinoacetate results reported as nmol/mL)

 

≤11 Months

12-23 Months

24-35 Months

Female

Male

Female

Male

Female

Male

Creatine

38.6-96.8

39.0-97.0

38.2-96.5

38.6-96.5

37.7-96.0

38.2-96.0

Creatinine

27.6-35.9

27.6-35.2

27.6-36.5

27.6-35.5

27.6-37.1

27.6-36.0

Guanidinoacetate

0.7-2.0

0.7-2.1

0.7-2.0

0.7-2.1

0.7-2.0

0.7-2.1

Creatine/
creatinine

≤3.07

≤3.60

≤3.02

≤3.54

≤2.96

≤3.48

Guanidinoacetate/
creatine

≤0.040

≤0.040

≤0.042

≤0.040

≤0.043

≤0.042

Guanidinoacetate/
creatinine

≤0.051

≤0.081

≤0.051

≤0.080

≤0.051

≤0.079

 

 

3 Years

4 Years

5 Years

Female

Male

Female

Male

Female

Male

Creatine

37.1-95.5

37.7-95.3

36.0-94.4

36.8-94.1

34.6-93.2

35.6-92.7

Creatinine

27.6-37.9

27.7-36.9

27.6-39.3

27.7-38.2

27.6-40.9

27.8-39.9

Guanidinoacetate

0.7-2.1

0.7-2.2

0.7-2.1

0.7-2.2

0.7-2.1

0.7-2.2

Creatine/
creatinine

≤2.89

≤3.40

≤2.77

≤3.26

≤2.64

≤3.09

Guanidinoacetate/
creatine

≤0.045

≤0.043

≤0.049

≤0.045

≤0.053

≤0.049

Guanidinoacetate/
creatinine

≤0.050

≤0.077

≤0.050

≤0.075

≤0.049

≤0.072

 

 

6 Years

7 Years

8 Years

Female

Male

Female

Male

Female

Male

Creatine

33.0-91.7

34.3-91.0

31.2-90.0

32.7-89.2

29.2-88.1

31.0-87.3

Creatinine

27.6-42.8

28.0-41.9

27.7-44.9

28.3-44.3

27.8-47.0

28.8-47.1

Guanidinoacetate

0.7-2.1

0.7-2.3

0.7-2.1

0.8-2.3

0.8-2.1

0.8-2.4

Creatine/
creatinine

≤2.49

≤2.91

≤2.33

≤2.70

≤2.17

≤2.49

Guanidinoacetate/
creatine

≤0.058

≤0.053

≤0.063

≤0.058

≤0.069

≤0.064

Guanidinoacetate/
creatinine

≤0.049

≤0.069

≤0.048

≤0.066

≤0.047

≤0.063

 

 

9 Years

10 Years

11 Years

Female

Male

Female

Male

Female

Male

Creatine

27.2-85.9

29.3-85.2

25.2-83.7

27.4-83.1

23.4-81.3

25.7-80.9

Creatinine

28.0-49.3

29.5-50.1

28.2-51.5

30.6-53.6

28.4-53.6

32.0-57.2

Guanidinoacetate

0.8-2.2

0.8-2.5

0.9-2.2

0.9-2.6

0.9-2.2

1.0-2.6

Creatine/
creatinine

≤2.02

≤2.28

≤1.86

≤2.07

≤1.72

≤1.87

Guanidinoacetate/
creatine

≤0.075

≤0.070

≤0.081

≤0.078

≤0.087

≤0.085

Guanidinoacetate/
creatinine

≤0.047

≤0.060

≤0.046

≤0.057

≤0.045

≤0.055

 

 

12 Years

13 Years

14 Years

Female

Male

Female

Male

Female

Male

Creatine

21.7-78.7

23.9-78.6

20.3-76.2

22.3-76.2

19.0-73.6

20.8-73.8

Creatinine

28.7-55.7

33.8-61.0

29.1-57.7

35.9-64.8

29.5-59.5

38.1-68.5

Guanidinoacetate

0.9-2.2

1.0-2.7

1.0-2.3

1.1-2.8

1.0-2.3

1.1-2.9

Creatine/
creatinine

≤1.58

≤1.68

≤1.45

≤1.50

≤1.33

≤1.34

Guanidinoacetate/
creatine

≤0.092

≤0.093

≤0.097

≤0.101

≤0.101

≤0.109

Guanidinoacetate/
creatinine

≤0.044

≤0.053

≤0.043

≤0.051

≤0.042

≤0.050

 

 

15 Years

16 Years

17 Years

Female

Male

Female

Male

Female

Male

Creatine

18.1-71.1

19.5-71.2

17.4-68.7

18.4-68.6

16.9-66.5

17.4-65.9

Creatinine

29.9-61.3

40.4-71.9

30.4-62.9

42.4-75.0

30.9-64.4

44.2-77.6

Guanidinoacetate

1.0-2.3

1.2-2.9

1.1-2.3

1.3-3.0

1.1-2.3

1.3-3.1

Creatine/
creatinine

≤1.22

≤1.20

≤1.12

≤1.07

≤1.04

≤0.97

Guanidinoacetate/
creatine

≤0.104

≤0.117

≤0.107

≤0.125

≤0.109

≤0.132

Guanidinoacetate/
creatinine

≤0.041

≤0.049

≤0.040

≤0.048

≤0.040

≤0.048

 

 

18 Years

19 Years

20 Years

Female

Male

Female

Male

Female

Male

Creatine

16.7-64.4

16.6-63.3

16.6-62.7

15.8-60.7

16.5-61.1

15.2-58.3

Creatinine

31.3-65.8

45.6-80.0

31.8-67.0

46.7-82.0

32.2-68.2

47.4-83.9

Guanidinoacetate

1.1-2.4

1.4-3.1

1.1-2.4

1.4-3.2

1.1-2.4

1.5-3.2

Creatine/
creatinine

≤0.98

≤0.87

≤0.93

≤0.80

≤0.89

≤0.73

Guanidinoacetate/
creatine

≤0.111

≤0.139

≤0.112

≤0.145

≤0.113

≤0.150

Guanidinoacetate/
creatinine

≤0.039

≤0.047

≤0.038

≤0.047

≤0.038

≤0.046

 

 

21 Years

22 Years

23 Years

Female

Male

Female

Male

Female

Male

Creatine

16.6-59.8

14.7-56.0

16.6-58.8

14.2-54.0

16.7-57.9

13.7-52.2

Creatinine

32.5-69.2

47.9-85.6

 32.8-70.2

48.2-87.2

 33.1-71.1

48.4-88.8

Guanidinoacetate

1.1-2.4

1.5-3.2

1.1-2.5

1.5-3.3

1.1-2.5

1.6-3.3

Creatine/
creatinine

≤0.87

≤0.68

≤0.85

≤0.64

≤0.84

≤0.61

Guanidinoacetate/
creatine

≤0.114

≤0.156

≤0.115

≤0.161

≤0.116

≤0.165

Guanidinoacetate/
creatinine

≤0.037

≤0.045

≤0.037

≤0.045

≤0.037

≤0.044

 

 

24 Years

25 Years

26 Years

Female

Male

Female

Male

Female

Male

Creatine

16.7-57.2

13.3-50.6

16.7-56.5

12.9-49.3

16.7-56.0

12.5-48.1

Creatinine

33.3-71.9

48.6-90.2

33.6-72.8

48.7-91.5

33.7-73.6

48.9-92.7

Guanidinoacetate

1.1-2.5

1.6-3.3

1.1-2.5

1.6-3.3

1.1-2.6

1.6-3.4

Creatine/
creatinine

≤0.84

≤0.58

≤0.84

≤0.56

≤0.84

≤0.54

Guanidinoacetate/
creatine

≤0.116

≤0.170

≤0.117

≤0.174

≤0.118

≤0.179

Guanidinoacetate/
creatinine

≤0.036

≤0.043

≤0.036

≤0.043

≤0.036

≤0.042

 

 

27 Years

28 Years

29 Years

Female

Male

Female

Male

Female

Male

Creatine

16.7-55.5

12.1-47.1

16.6-55.1

11.8-46.3

16.5-54.7

11.5-45.4

Creatinine

33.9-74.4

49.0-93.7

34.1-75.2

49.1-94.5

34.2-76.0

49.2-95.3

Guanidinoacetate

1.1-2.6

1.6-3.4

1.1-2.6

1.6-3.4

1.1-2.6

1.6-3.4

Creatine/
creatinine

≤0.84

≤0.52

≤0.84

≤0.51

≤0.84

≤0.49

Guanidinoacetate/
creatine

≤0.118

≤0.182

≤0.119

≤0.186

≤0.119

≤0.188

Guanidinoacetate/
creatinine

≤0.036

≤0.042

≤0.036

≤0.041

≤0.036

≤0.041

 

 

30 Years

31 Years

32 Years

Female

Male

Female

Male

Female

Male

Creatine

16.4-54.2

11.3-44.7

16.4-53.8

11.1-43.9

16.3-53.4

11.0-43.2

Creatinine

34.4-76.8

49.3-96.0

34.6-77.5

49.3-96.7

34.7-78.2

49.4-97.4

Guanidinoacetate

1.2-2.7

1.6-3.5

1.2-2.7

1.6-3.5

1.2-2.7

1.6-3.5

Creatine/
creatinine

≤0.84

≤0.48

≤0.83

≤0.47

≤0.83

≤0.46

Guanidinoacetate/
creatine

≤0.120

≤0.190

≤0.120

≤0.192

≤0.119

≤0.192

Guanidinoacetate/
creatinine

≤0.036

≤0.041

≤0.036

≤0.042

≤0.037

≤0.042

 

 

33 Years

34 Years

35 Years

Female

Male

Female

Male

Female

Male

Creatine

16.3-53.0

10.9-42.5

16.4-52.7

10.8-41.7

16.4-52.3

10.7-41.0

Creatinine

34.9-78.8

49.4-98.0

35.1-79.4

49.5-98.6

35.3-79.9

49.5-99.2

Guanidinoacetate

1.2-2.8

1.6-3.5

1.2-2.8

1.6-3.5

1.2-2.8

1.6-3.4

Creatine/
creatinine

≤0.82

≤0.45

≤0.82

≤0.45

≤0.82

≤0.44

Guanidinoacetate/
creatine

≤0.119

≤0.192

≤0.118

≤0.191

≤0.118

≤0.189

Guanidinoacetate/
creatinine

≤0.037

≤0.042

≤0.037

≤0.042

≤0.037

≤0.042

 

 

36 Years

37 Years

38 Years

Female

Male

Female

Male

Female

Male

Creatine

16.5-52.0

10.7-40.2

16.7-51.6

10.6-39.5

16.9-51.3

10.6-38.9

Creatinine

35.4-80.3

49.5-99.8

35.6-80.7

49.5-100.3

35.8-81.0

49.6-100.8

Guanidinoacetate

1.2-2.8

1.6-3.4

1.2-2.8

1.6-3.4

1.2-2.9

1.6-3.4

Creatine/
creatinine

≤0.82

≤0.44

≤0.82

≤0.44

≤0.83

≤0.44

Guanidinoacetate/
creatine

≤0.117

≤0.187

≤0.115

≤0.184

≤0.114

≤0.182

Guanidinoacetate/
creatinine

≤0.037

≤0.042

≤0.037

≤0.042

≤0.036

≤0.042

 

 

39 Years

40 Years

41 Years

Female

Male

Female

Male

Female

Male

Creatine

17.1-51.1

10.6-38.2

17.3-50.9

10.7-37.7

17.5-50.8

10.7-37.2

Creatinine

35.9-81.4

49.6-101.3

36.0-81.6

49.6-101.7

36.1-81.9

49.7-102.1

Guanidinoacetate

1.2-2.9

1.6-3.4

1.2-2.9

1.6-3.4

1.2-2.9

1.6-3.4

Creatine/
creatinine

≤0.83

≤0.44

≤0.83

≤0.44

≤0.84

≤0.44

Guanidinoacetate/
creatine

≤0.113

≤0.179

≤0.111

≤0.176

≤0.110

≤0.174

Guanidinoacetate/
creatinine

≤0.036

≤0.041

≤0.036

≤0.041

≤0.036

≤0.040

 

 

42 Years

43 Years

44 Years

Female

Male

Female

Male

Female

Male

Creatine

17.7-50.8

10.8-36.7

17.8-50.8

10.9-36.3

17.8-50.9

11.0-36.0

Creatinine

36.2-82.1

49.7-102.5

36.3-82.4

49.8-102.8

36.4-82.6

49.8-103.1

Guanidinoacetate

1.2-3.0

1.6-3.3

1.2-3.0

1.6-3.3

1.2-3.0

1.6-3.3

Creatine/
creatinine

≤0.84

≤0.44

≤0.84

≤0.43

≤0.84

≤0.43

Guanidinoacetate/
creatine

≤0.109

≤0.172

≤0.108

≤0.171

≤0.107

≤0.170

Guanidinoacetate/
creatinine

≤0.036

≤0.039

≤0.036

≤0.039

≤0.036

≤0.038

 

 

45 Years

46 Years

47 Years

Female

Male

Female

Male

Female

Male

Creatine

17.7-51.0

11.1-35.6

17.6-51.2

11.2-35.3

17.4-51.4

11.3-35.1

Creatinine

36.4-82.8

49.9-103.4

36.5-83.0

49.9-103.6

36.5-83.2

49.9-103.9

Guanidinoacetate

1.2-3.0

1.7-3.3

1.2-3.1

1.7-3.3

1.2-3.1

1.7-3.3

Creatine/
creatinine

≤0.84

≤0.42

≤0.83

≤0.41

≤0.83

≤0.40

Guanidinoacetate/
creatine

≤0.106

≤0.169

≤0.106

≤0.168

≤0.106

≤0.167

Guanidinoacetate/
creatinine

≤0.037

≤0.038

≤0.037

≤0.037

≤0.037

≤0.037

 

 

48 Years

49 Years

50 Years

Female

Male

Female

Male

Female

Male

Creatine

17.2-51.7

11.5-34.8

17.1-51.9

11.6-34.6

17.0-52.1

11.7-34.4

Creatinine

36.6-83.4

49.9-104.1

36.6-83.5

49.9-104.2

36.7-83.7

49.9-104.4

Guanidinoacetate

1.2-3.1

1.7-3.3

1.2-3.1

1.7-3.3

1.2-3.1

1.7-3.3

Creatine/
creatinine

≤0.82

≤0.39

≤0.82

≤0.38

≤0.82

≤0.38

Guanidinoacetate/
creatine

≤0.106

≤0.166

≤0.106

≤0.164

≤0.105

≤0.163

Guanidinoacetate/
creatinine

≤0.038

≤0.036

≤0.038

≤0.036

≤0.039

≤0.036

 

 

51 Years

52 Years

53 Years

Female

Male

Female

Male

Female

Male

Creatine

17.0-52.2

11.9-34.3

17.1-52.3

12.0-34.3

17.3-52.4

12.2-34.3

Creatinine

36.8-83.9

49.8-104.6

36.8-84.0

49.8-104.8

36.9-84.2

49.8-104.9

Guanidinoacetate

1.2-3.1

1.7-3.3

1.2-3.1

1.7-3.2

1.2-3.1

1.6-3.2

Creatine/
creatinine

≤0.82

≤0.37

≤0.82

≤0.37

≤0.82

≤0.38

Guanidinoacetate/
creatine

≤0.105

≤0.161

≤0.104

≤0.159

≤0.103

≤0.157

Guanidinoacetate/
creatinine

≤0.039

≤0.036

≤0.039

≤0.036

≤0.039

≤0.036

 

 

54 Years

55 Years

56 Years

Female

Male

Female

Male

Female

Male

Creatine

17.6-52.5

12.4-34.3

18.1-52.6

12.5-34.4

18.6-52.7

12.6-34.4

Creatinine

37.0-84.4

49.8-105.0

37.1-84.5

49.8-105.2

37.2-84.7

49.8-105.3

Guanidinoacetate

1.2-3.1

1.6-3.2

1.2-3.1

1.6-3.2

1.2-3.1

1.6-3.2

Creatine/
creatinine

≤0.82

≤0.38

≤0.83

≤0.39

≤0.84

≤0.40

Guanidinoacetate/
creatine

≤0.102

≤0.155

≤0.100

≤0.154

≤0.099

≤0.152

Guanidinoacetate/
creatinine

≤0.039

≤0.036

≤0.039

≤0.036

≤0.039

≤0.036

 

 

57 Years

58 Years

59 Years

Female

Male

Female

Male

Female

Male

Creatine

19.2-52.9

12.7-34.4

19.9-53.1

12.8-34.3

20.5-53.3

12.8-34.2

Creatinine

37.3-84.9

49.8-105.4

37.4-85.1

49.8-105.5

37.6-85.2

49.8-105.6

Guanidinoacetate

1.2-3.0

1.6-3.2

1.3-3.0

1.6-3.2

1.3-3.0

1.6-3.2

Creatine/
creatinine

≤0.84

≤0.40

≤0.85

≤0.41

≤0.86

≤0.42

Guanidinoacetate/
creatine

≤0.098

≤0.151

≤0.096

≤0.151

≤0.095

≤0.150

Guanidinoacetate/
creatinine

≤0.039

≤0.036

≤0.038

≤0.036

≤0.038

≤0.036

 

 

60 Years

61 Years

62 Years

Female

Male

Female

Male

Female

Male

Creatine

21.0-53.6

12.8-34.1

21.5-53.9

12.7-34.0

21.9-54.2

12.6-33.9

Creatinine

37.8-85.4

49.9-105.7

38.0-85.5

49.9-105.9

38.3-85.7

49.9-106.0

Guanidinoacetate

1.3-2.9

1.6-3.2

1.3-2.9

1.6-3.1

1.3-2.9

1.6-3.1

Creatine/
creatinine

≤0.87

≤0.43

≤0.87

≤0.44

≤0.88

≤0.44

Guanidinoacetate/
creatine

≤0.094

≤0.150

≤0.093

≤0.150

≤0.093

≤0.150

Guanidinoacetate/
creatinine

≤0.037

≤0.036

≤0.036

≤0.035

≤0.036

≤0.035

 

 

63 Years

64 Years

65 Years

Female

Male

Female

Male

Female

Male

Creatine

22.2-54.6

12.4-33.7

22.3-55.0

12.3-33.6

22.5-55.5

12.2-33.4

Creatinine

38.7-85.8

50.0-106.1

39.1-85.9

50.0-106.3

39.6-86.1

50.1-106.4

Guanidinoacetate

1.3-2.8

1.6-3.1

1.3-2.8

1.6-3.1

1.3-2.8

1.6-3.1

Creatine/
creatinine

≤0.88

≤0.45

≤0.89

≤0.46

≤0.89

≤0.46

Guanidinoacetate/
creatine

≤0.092

≤0.150

≤0.092

≤0.149

≤0.091

≤0.149

Guanidinoacetate/
creatinine

≤0.035

≤0.035

≤0.034

≤0.034

≤0.034

≤0.034

 

 

66 Years

67 Years

68 Years

Female

Male

Female

Male

Female

Male

Creatine

22.6-55.9

12.3-33.1

22.7-56.3

12.3-32.8

22.9-56.7

12.5-32.4

Creatinine

40.2-86.2

50.2-106.6

40.7-86.3

50.3-106.7

41.3-86.5

50.4-106.9

Guanidinoacetate

1.3-2.7

1.6-3.1

1.3-2.7

1.6-3.0

1.4-2.7

1.6-3.0

Creatine/
creatinine

≤0.90

≤0.47

≤0.90

≤0.48

≤0.90

≤0.48

Guanidinoacetate/
creatine

≤0.091

≤0.149

≤0.090

≤0.148

≤0.090

≤0.148

Guanidinoacetate/
creatinine

≤0.034

≤0.034

≤0.033

≤0.034

≤0.033

≤0.034

 

 

69 Years

70 Years

≥ 71 Years

Female

Male

Female

Male

Female

Male

Creatine

23.2-57.0

12.8-32.0

23.6-57.2

13.1-31.4

24.1-57.3

13.6-30.8

Creatinine

41.9-86.6

50.5-107.1

42.4-86.8

50.7-107.4

42.8-86.9

50.8-107.6

Guanidinoacetate

1.4-2.6

1.6-3.0

1.4-2.6

1.6-3.0

1.4-2.5

1.5-3.0

Creatine/
creatinine

≤0.90

≤0.48

≤0.90

≤0.48

≤0.90

≤0.48

Guanidinoacetate/
creatine

≤0.090

≤0.148

≤0.090

≤0.148

≤0.090

≤0.148

Guanidinoacetate/
creatinine

≤0.033

≤0.034

≤0.033

≤0.034

≤0.033

≤0.034

Day(s) Performed

Tuesday

Report Available

3 to 9 days

Specimen Retention Time

1 month

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82540

82565

82542