Ordering Guidance

This test should not be used to screen for BCR::ABL1 fusions at the time of diagnosis. For diagnostic evaluation, order BADX / BCR/ABL1, Qualitative, Diagnostic Assay, Varies; or BCRFX / BCR/ABL1 Qualitative Diagnostic Assay with Reflex to BCR/ABL1 p190 Quantitative Assay or p210 Quantitative Assay, Varies.

For measurable residual disease (MRD) monitoring of patients with chronic myeloid leukemia (CML) or, less commonly, B-cell acute lymphoblastic leukemia (B-ALL) or acute myeloid leukemia (AML) with a previously identified p210 (e13/e14-a2) fusion transcript, order BCRAB / BCR/ABL1, p210, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Chronic Myelogenous Leukemia (CML), Varies.

For MRD monitoring of B-ALL or rare CML or AML patients with a previously identified p190 (e1-a2) fusion transcript, order BA190 test / BCR/ABL1, p190, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Assay, Varies.

For more information, see BCR/ABL1 Ordering Guide for Blood and Bone Marrow

Shipping Instructions

Ambient specimens must arrive within 3 days (72 hours) of collection. Refrigerated specimens must arrive within 5 days of collection. Collect and package specimens as close to shipping time as possible.

Necessary Information

The following information is required:

1. Pertinent clinical history including if the patient has a diagnosis of chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, or other BCR::ABL1-positive neoplasm

2. Specific fusion transcript if previously determined

3. Date of collection

4. Specimen source (blood or bone marrow)

Specimen Required

Submit only 1 of the following specimens:

Specimen Type: Whole blood

Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Yellow top (ACD)

Specimen Volume: 10 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send whole blood specimen in original tube. Do not aliquot.

3. Label specimen as blood.

Specimen Type: Bone marrow

Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Yellow top (ACD)

Specimen Volume: 4 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send bone marrow specimen in original tube. Do not aliquot.

3. Label specimen as bone marrow.