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HelpTest Code CHRCV Chromosome Analysis, Chorionic Villus Sampling
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| _ML15 | Metaphases, <15 | No, (Bill Only) | No |
| _M15 | Metaphases, 15 | No, (Bill Only) | No |
| _MG14 | Metaphases, >15 | No, (Bill Only) | No |
| _KTG1 | Karyotypes, >1 | No, (Bill Only) | No |
| _STAC | Ag-Nor/CBL Stain | No, (Bill Only) | No |
Specimen Type
TissueOrdering Guidance
This test should be performed for prenatal diagnostic purposes only. A chromosomal microarray (CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling) is recommended, rather than chromosomal analysis, to detect clinically relevant gains or losses of chromosomal material in pregnancies with 1 or more major structural abnormalities. Chromosomal microarray can also be considered, rather than chromosome analysis, for patients undergoing invasive prenatal diagnostic testing with a structurally normal fetus.
Portions of the specimen may be used for other tests such as molecular genetic testing, biochemical testing, and fluorescence in situ hybridization (FISH) testing (including PADF / Prenatal Aneuploidy Detection, FISH). If additional molecular genetic or biochemical genetic testing is needed, order CULFB / Fibroblast Culture for Genetic Test so that cell cultures may be set up specifically for the use in these tests.
Shipping Instructions
Advise Express Mail or equivalent if not on courier service.
Necessary Information
Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
Specimen Required
Specimen Type: Chorionic villi
Supplies: CVS Media (RPMI) and Small Dish (T095)
Container/Tube: 15-mL tube containing 15 mL of transport media
Specimen Volume: 20-30 mg
Collection Instructions:
1. Collect chorionic villus specimen (CVS) by the transabdominal or transcervical method.
2. Transfer the CVS to a Petri dish containing transport medium (Such as CVS Media [RPMI] and Small Dish [T095]).
3. Using a stereomicroscope and sterile forceps, assess the quality and quantity of the villi and remove any blood clots and maternal decidua.
4. If ordering with PADF / Prenatal Aneuploidy Detection, FISH, submit a minimum of 14 mg.
5. If ordering with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling, submit a minimum of 24 mg.
6. If ordering with both PADF and CMAP, then submit a minimum of 26 mg.
Specimen Minimum Volume
The following is the minimum volume when only this test is ordered:
12 mg
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Tissue | Refrigerated (preferred) | ||
| Ambient | |||
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
9 to 14 daysSpecimen Retention Time
Any remaining specimen is discarded at the time results are reported.Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
88235, 88291-Tissue culture for amniotic fluid or chorionic villus cells, Interpretation and report
88267 w/modifier 52-Chromosome analysis, amniotic fluid or chorionic villus, <15 cells, 1 karyotype with banding (if appropriate)
88267-Chromosome analysis, amniotic fluid or chorionic villus, 15 cells, 1 karyotype with banding (if appropriate)
88267, 88285-Chromosome analysis, amniotic fluid or chorionic villus, <15 cells, 1 karyotype with banding (if appropriate)
Genetics Test Information
Cultures from this specimen will be discarded 10 days after all cytogenetic test results have been reported. If further testing is desired, call the laboratory at 800-533-1710.